Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus.
Identifieur interne : 001602 ( Main/Exploration ); précédent : 001601; suivant : 001603Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus.
Auteurs : Fumihiko Yasui [Japon] ; Michinori Kohara [Japon] ; Masahiro Kitabatake [Japon] ; Tetsu Nishiwaki [Japon] ; Hideki Fujii [Japon] ; Chise Tateno [Japon] ; Misako Yoneda [Japon] ; Kouichi Morita [Japon] ; Kouji Matsushima [Japon] ; Shigeo Koyasu [Japon] ; Chieko Kai [Japon]Source :
- Virology [ 1096-0341 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps neutralisants (immunologie), Femelle, Immunisation passive, Lymphocytes B (immunologie), Lymphocytes T CD4+ (immunologie), Modèles animaux de maladie humaine, Phagocytes (immunologie), Poumon (immunologie), Souris, Souris SCID, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (immunologie), Transfert adoptif, Virus du SRAS (immunologie).
- MESH :
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Lymphocytes B, Lymphocytes T CD4+, Phagocytes, Poumon, Syndrome respiratoire aigu sévère, Virus du SRAS.
- Animaux, Femelle, Immunisation passive, Modèles animaux de maladie humaine, Souris, Souris SCID, Souris de lignée BALB C, Transfert adoptif.
English descriptors
- KwdEn :
- Adoptive Transfer, Animals, Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), B-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (immunology), Disease Models, Animal, Female, Immunization, Passive, Lung (immunology), Mice, Mice, Inbred BALB C, Mice, SCID, Phagocytes (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology).
- MESH :
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral.
- immunology : B-Lymphocytes, CD4-Positive T-Lymphocytes, Lung, Phagocytes, SARS Virus, Severe Acute Respiratory Syndrome.
- Adoptive Transfer, Animals, Disease Models, Animal, Female, Immunization, Passive, Mice, Mice, Inbred BALB C, Mice, SCID.
Abstract
While the 2002-2003 outbreak of severe acute respiratory syndrome (SARS) resulted in 774 deaths, patients who were affected with mild pulmonary symptoms successfully recovered. The objective of the present work was to identify, using SARS coronavirus (SARS-CoV) mouse infection models, immune factors responsible for clearing of the virus. The elimination of pulmonary SARS-CoV infection required the activation of B cells by CD4(+) T cells. Furthermore, passive immunization (post-infection) with homologous (murine) anti-SARS-CoV antiserum showed greater elimination efficacy against SARS-CoV than that with heterologous (rabbit) antiserum, despite the use of equivalent titers of neutralizing antibodies. This distinction was mediated by mouse phagocytic cells (monocyte-derived infiltrating macrophages and partially alveolar macrophages, but not neutrophils), as demonstrated both by adoptive transfer from donors and by immunological depletion of selected cell types. These results indicate that the cooperation of anti-SARS-CoV antibodies and phagocytic cells plays an important role in the elimination of SARS-CoV.
DOI: 10.1016/j.virol.2014.02.005
PubMed: 24725942
Affiliations:
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Electronic address: kohara-mc@igakuken.or.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kitabatake, Masahiro" sort="Kitabatake, Masahiro" uniqKey="Kitabatake M" first="Masahiro" last="Kitabatake">Masahiro Kitabatake</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Immunology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556</wicri:regionArea><wicri:noRegion>Kumamoto 860-8556</wicri:noRegion></affiliation></author><author><name sortKey="Nishiwaki, Tetsu" sort="Nishiwaki, Tetsu" uniqKey="Nishiwaki T" first="Tetsu" last="Nishiwaki">Tetsu Nishiwaki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Fujii, Hideki" sort="Fujii, Hideki" uniqKey="Fujii H" first="Hideki" last="Fujii">Hideki Fujii</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Immunology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0213, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Immunology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0213</wicri:regionArea><wicri:noRegion>Okinawa 903-0213</wicri:noRegion></affiliation></author><author><name sortKey="Tateno, Chise" sort="Tateno, Chise" uniqKey="Tateno C" first="Chise" last="Tateno">Chise Tateno</name><affiliation wicri:level="1"><nlm:affiliation>PhoenixBio Co., Ltd., 3-4-1 Kagamiyama, Higashihiroshima 739-0046, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>PhoenixBio Co., Ltd., 3-4-1 Kagamiyama, Higashihiroshima 739-0046</wicri:regionArea><wicri:noRegion>Higashihiroshima 739-0046</wicri:noRegion></affiliation></author><author><name sortKey="Yoneda, Misako" sort="Yoneda, Misako" uniqKey="Yoneda M" first="Misako" last="Yoneda">Misako Yoneda</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Morita, Kouichi" sort="Morita, Kouichi" uniqKey="Morita K" first="Kouichi" last="Morita">Kouichi Morita</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523</wicri:regionArea><wicri:noRegion>Nagasaki 852-8523</wicri:noRegion></affiliation></author><author><name sortKey="Matsushima, Kouji" sort="Matsushima, Kouji" uniqKey="Matsushima K" first="Kouji" last="Matsushima">Kouji Matsushima</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Koyasu, Shigeo" sort="Koyasu, Shigeo" uniqKey="Koyasu S" first="Shigeo" last="Koyasu">Shigeo Koyasu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Laboratory for Immune Cell System, RCAI, RIKEN Research Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Yokohama 230-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Laboratory for Immune Cell System, RCAI, RIKEN Research Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Yokohama 230-0045</wicri:regionArea><wicri:noRegion>Yokohama 230-0045</wicri:noRegion></affiliation></author><author><name sortKey="Kai, Chieko" sort="Kai, Chieko" uniqKey="Kai C" first="Chieko" last="Kai">Chieko Kai</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24725942</idno><idno type="pmid">24725942</idno><idno type="doi">10.1016/j.virol.2014.02.005</idno><idno type="wicri:Area/PubMed/Corpus">001012</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001012</idno><idno type="wicri:Area/PubMed/Curation">001012</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001012</idno><idno type="wicri:Area/PubMed/Checkpoint">000F55</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F55</idno><idno type="wicri:Area/Ncbi/Merge">002869</idno><idno type="wicri:Area/Ncbi/Curation">002869</idno><idno type="wicri:Area/Ncbi/Checkpoint">002869</idno><idno type="wicri:Area/Main/Merge">001607</idno><idno type="wicri:Area/Main/Curation">001602</idno><idno type="wicri:Area/Main/Exploration">001602</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus.</title><author><name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. Electronic address: kohara-mc@igakuken.or.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kitabatake, Masahiro" sort="Kitabatake, Masahiro" uniqKey="Kitabatake M" first="Masahiro" last="Kitabatake">Masahiro Kitabatake</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Immunology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556</wicri:regionArea><wicri:noRegion>Kumamoto 860-8556</wicri:noRegion></affiliation></author><author><name sortKey="Nishiwaki, Tetsu" sort="Nishiwaki, Tetsu" uniqKey="Nishiwaki T" first="Tetsu" last="Nishiwaki">Tetsu Nishiwaki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Fujii, Hideki" sort="Fujii, Hideki" uniqKey="Fujii H" first="Hideki" last="Fujii">Hideki Fujii</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Immunology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0213, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Immunology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0213</wicri:regionArea><wicri:noRegion>Okinawa 903-0213</wicri:noRegion></affiliation></author><author><name sortKey="Tateno, Chise" sort="Tateno, Chise" uniqKey="Tateno C" first="Chise" last="Tateno">Chise Tateno</name><affiliation wicri:level="1"><nlm:affiliation>PhoenixBio Co., Ltd., 3-4-1 Kagamiyama, Higashihiroshima 739-0046, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>PhoenixBio Co., Ltd., 3-4-1 Kagamiyama, Higashihiroshima 739-0046</wicri:regionArea><wicri:noRegion>Higashihiroshima 739-0046</wicri:noRegion></affiliation></author><author><name sortKey="Yoneda, Misako" sort="Yoneda, Misako" uniqKey="Yoneda M" first="Misako" last="Yoneda">Misako Yoneda</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Morita, Kouichi" sort="Morita, Kouichi" uniqKey="Morita K" first="Kouichi" last="Morita">Kouichi Morita</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523</wicri:regionArea><wicri:noRegion>Nagasaki 852-8523</wicri:noRegion></affiliation></author><author><name sortKey="Matsushima, Kouji" sort="Matsushima, Kouji" uniqKey="Matsushima K" first="Kouji" last="Matsushima">Kouji Matsushima</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Koyasu, Shigeo" sort="Koyasu, Shigeo" uniqKey="Koyasu S" first="Shigeo" last="Koyasu">Shigeo Koyasu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Laboratory for Immune Cell System, RCAI, RIKEN Research Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Yokohama 230-0045, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Laboratory for Immune Cell System, RCAI, RIKEN Research Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Yokohama 230-0045</wicri:regionArea><wicri:noRegion>Yokohama 230-0045</wicri:noRegion></affiliation></author><author><name sortKey="Kai, Chieko" sort="Kai, Chieko" uniqKey="Kai C" first="Chieko" last="Kai">Chieko Kai</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j">Virology</title><idno type="eISSN">1096-0341</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adoptive Transfer</term><term>Animals</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (immunology)</term><term>B-Lymphocytes (immunology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Disease Models, Animal</term><term>Female</term><term>Immunization, Passive</term><term>Lung (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, SCID</term><term>Phagocytes (immunology)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps neutralisants (immunologie)</term><term>Femelle</term><term>Immunisation passive</term><term>Lymphocytes B (immunologie)</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Phagocytes (immunologie)</term><term>Poumon (immunologie)</term><term>Souris</term><term>Souris SCID</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Transfert adoptif</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Lymphocytes B</term><term>Lymphocytes T CD4+</term><term>Phagocytes</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term><term>CD4-Positive T-Lymphocytes</term><term>Lung</term><term>Phagocytes</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adoptive Transfer</term><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Immunization, Passive</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, SCID</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Immunisation passive</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Souris SCID</term><term>Souris de lignée BALB C</term><term>Transfert adoptif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">While the 2002-2003 outbreak of severe acute respiratory syndrome (SARS) resulted in 774 deaths, patients who were affected with mild pulmonary symptoms successfully recovered. The objective of the present work was to identify, using SARS coronavirus (SARS-CoV) mouse infection models, immune factors responsible for clearing of the virus. The elimination of pulmonary SARS-CoV infection required the activation of B cells by CD4(+) T cells. Furthermore, passive immunization (post-infection) with homologous (murine) anti-SARS-CoV antiserum showed greater elimination efficacy against SARS-CoV than that with heterologous (rabbit) antiserum, despite the use of equivalent titers of neutralizing antibodies. This distinction was mediated by mouse phagocytic cells (monocyte-derived infiltrating macrophages and partially alveolar macrophages, but not neutrophils), as demonstrated both by adoptive transfer from donors and by immunological depletion of selected cell types. These results indicate that the cooperation of anti-SARS-CoV antibodies and phagocytic cells plays an important role in the elimination of SARS-CoV.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name></region><name sortKey="Fujii, Hideki" sort="Fujii, Hideki" uniqKey="Fujii H" first="Hideki" last="Fujii">Hideki Fujii</name><name sortKey="Kai, Chieko" sort="Kai, Chieko" uniqKey="Kai C" first="Chieko" last="Kai">Chieko Kai</name><name sortKey="Kitabatake, Masahiro" sort="Kitabatake, Masahiro" uniqKey="Kitabatake M" first="Masahiro" last="Kitabatake">Masahiro Kitabatake</name><name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name><name sortKey="Koyasu, Shigeo" sort="Koyasu, Shigeo" uniqKey="Koyasu S" first="Shigeo" last="Koyasu">Shigeo Koyasu</name><name sortKey="Matsushima, Kouji" sort="Matsushima, Kouji" uniqKey="Matsushima K" first="Kouji" last="Matsushima">Kouji Matsushima</name><name sortKey="Morita, Kouichi" sort="Morita, Kouichi" uniqKey="Morita K" first="Kouichi" last="Morita">Kouichi Morita</name><name sortKey="Nishiwaki, Tetsu" sort="Nishiwaki, Tetsu" uniqKey="Nishiwaki T" first="Tetsu" last="Nishiwaki">Tetsu Nishiwaki</name><name sortKey="Tateno, Chise" sort="Tateno, Chise" uniqKey="Tateno C" first="Chise" last="Tateno">Chise Tateno</name><name sortKey="Yoneda, Misako" sort="Yoneda, Misako" uniqKey="Yoneda M" first="Misako" last="Yoneda">Misako Yoneda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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